基本資料
姓名 許瑞芬
職稱 教授
辦公室分機 02 2905 2512
實驗室分機 02 2905 3619
E-mail 034825@mail.fju.edu.tw
專長
  • 營養生化
  • 分子細胞營養學
  • 營養基因體學
  • 葉酸營養與癌症預防
  • 葉酸分子流病學與臨床營養研究
研究方向
  • 營養與基因體學
  • 營養與癌症預防
  • 葉酸營養單碳代謝調節
  • 細胞分子傳訊機制與癌化作用
  • 粒線體與氧化壓力
主要學歷
  • Fu-Jen University, Taipei, Taiwan 1982/0~1986/0 Bachelor of Science, Nutrition and Food Sciences
  • Kansas State University, Kansas, USA 1986/0~1988/0 Master of Science, Nutrition
  • University of California, Berkeley, USA 1988/0~1993/0 Doctor of Philosophy, Nutritional Science & Toxicology
學術研究成果
  • 學術期刊論文
  • 1. Kuo CS, Huang CY, Kuo HT, Cheng CP, Chen CH, Lu CL, Yang FLO, Huang RFS*. Interrelationships among genetic C677T polymorphism of 5,10-methylenetetrahydrofolate reductase, biochemical folate status, and lymphocytic p53 oxidative damage in association with tumor malignancy and survivals of patients with hepatocellular carcinoma. Mol. Nutr. Food Res. 2013,00:1-14. (SCI:4/124, IF:4.310)
  • 2.Wang TP, Shu CH, Fang SC, and Huang RFS*. Folate deprivation enhanced invasiveness of human colon cancer cells mediated by activation of sonic hedgehog signaling through its promoter hypomethylation and cross-action with transcription nuclear factor-kappa B pathway. Carcinogenesis. 2012;33:1158-68. (SCI:28/196, IF: 5.402 )
  • 3.Chen TF, Huang RFS, Lin SE, Chiu MJ. Synergic effect of folic acid and memantine on spatial learning and neuronal protection in an Alzheimer’s transgenic model. J Alzheimers Dis. 2010;20:607-15. (SCI:64/251, IF:4.174 )
  • 4. Ye YL, Chan YT, Liu HC, Lu HT, and Huang RFS*. Depleted folate pool and dysfunctional mitochondria associated with defective mitochondrial folate proteins sensitize Chinese ovary cell mutants to tert-butylhydroperoxide–induced oxidative stress and apoptosis. J Nutr Biochem. 2010 ;21(9):793-800. (SCI:8/76 , IF: 4.538)
  • 5. Chou YF, HuangRFS*. Mitochondrial DNA deletions of blood lymphocytes as geneticmarkers of low folate-related mitochondrial genotoxicity in peripheral tissues. Euro J Nutr. 2009;48:429-36. (SCI:22/76 , IF: 3.127)
  • 6. Wu MY , Kuo CS, Lin CY, Lu CL, HuangRFS*. Lymphocytic mitochondrial DNA deletions, biochemical folate status and hepatocellular carcinoma susceptibility in a case–control study. Br J Nutr. 2009;102:715-721.(SCI: 18/76 , IF: 3.072)
  • 7. Kuo CS, Lin CY, Wu MY, Lu CL, Huang RFS*. Relationship between folate status and tumour progression in patients with hepatocellular carcinoma. Br J Nutr. 2008;100: 596-602. (SCI:18/76 , IF: 3.302)
  • 8. Chou YF, Yu CC, Huang RFS*. Changes in mitochondrial (mt) DNA in folate-deficient tissues of young rats depend on mt folate, mt biogenesis, and oxidative DNA injuries. J Nutr. 2007;137:2036-2042. (SCI:10/76 , IF: 4.295)
  • 9.Chang CM, Yu CC, Lu HT, Chou YF, Huang RFS*. Folate deprivation promotes mitochondrial oxidative decay: DNA large deletions, cytochrome c oxidase dysfunction, membrane depolarization and superoxide overproduction in rat liver. Br J Nutr. 2007;97:855-863. (SCI:18/76 , IF: 3.302)
  • 10.Huang RF, Huang SM, Lin BS, Hung CY, Lu HT. N-Acetylcysteine, vitamin C and vitamin E diminish homocysteine thiolactone-induced apoptosis in human promyeloid HL-60 cells. J Nutr. 2002;132(8):2151-6. (SCI: , IF: 4.196)
  • 11. Huang RF, Hsu YC, Lin HL, Yang FL. Folate depletion and elevated plasma homocysteine promote oxidative stress in rat livers. J Nutr. 2001;131(1):33-8. (SCI: , IF: 4.196)
  • 12.Huang RF, Ho YH, Lin HL, Wei JS, Liu TZ. Folate deficiency induces a cell cycle-specific apoptosis in HepG2 cells. J Nutr. 1999;129(1):25-31. (SCI: , IF: 4.196)
  • 研討會論文
  • 1.周佳慧、陳達夫、邱銘章、許瑞芬,「葉酸補充調節類澱粉蛋白誘發神經母細胞瘤程式凋亡與粒線體養化傷害之機制」,台灣臨床失智症學會,2013年財團法人立夫醫藥文教基金會學術獎,2013年11月17日(佳作)
  • 2. 魏憶君、許瑞芬,「奈米金結合茄紅素協同誘導人類結腸癌細胞凋亡及作用分子機制」,第39屆營養年會暨學術研討會,台中,臺灣,台灣營養學會,2013年05月24日,頁PA-29
  • 3.陳鈴如、許瑞芬,「葉酸營養狀態調控人類肝癌細胞之氧化壓力與癌轉移相關傳訊分子機制」,台灣營養學會第39屆營養年會暨學術研討會,臺灣,2013年05月24日,頁PA-16
  • 4. 周佳慧、陳達夫、邱銘章、許瑞芬,「葉酸補充調節類澱粉蛋白誘發神經母細胞瘤對於粒線體氧化傷害之機制」,第39屆營養年會暨學術研討會,台中,臺灣,台灣營養學會,2013年05月24日,頁PA-8 (壁報論文競賽基礎營養組第三名)
  • 5.郭常勝、許瑞芬,「Genetic C677T polymorphisms of methylenetetrahydrofolate reductase and one-carbon metabolites as prognostic predictors for survival outcome of patients with hepatocellular carcinoma.」,Boston,USA,2013年04月20日,頁D337, 1077
  • 6. 許弘政、許瑞芬,「Treatment of late-stage Alzheimer’s disease with folate derivatives in the 3xTg-AD mice model.」,28th international conference of Alzheimer's disease international,台北,臺灣,2013年04月18日,頁P003, p130
  • 7. 許舒涵、許瑞芬,「葉酸營養調節人類結腸癌細胞Nuclear factor-kB與Hedgehog訊息傳遞路徑」,台灣營養學會第38屆年會暨學術研討會,台南,臺灣,台灣營養學會,2012年05月18日,頁PA-A-49 (壁報論文競賽基礎營養組第二名)
  • 8.馮馨醇、郭常勝、田宇峯、孫定平、李健逢、許瑞芬,「The role of folate status and methylenetetrahydrofolate reductase gene C677T polymorphism in sonic hedgehog signal and its altered methylation pattern in human colorectal carcinoma」,美國,2012年04月21日
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